There were an estimated 135,000 people living with HIV/AIDS in California in 2012, a number that has grown faster than for any other state. To help impact and curb the California epidemic, CHRP launched several innovative and unique research initiatives. These include three initiatives to reduce the number of new HIV infections by testing and evaluating the HIV prevention pill, commonly called “PrEP” (Pre-Exposure Prophylaxis), in three key, at-risk populations. CHRP also launched initiatives to evaluate innovative new ways to provide HIV care services and developed initiatives to evaluate innovations in reducing HIV-related racial/ethnic and other disparities. The organization has received strong support from advocates and the CA legislature, enabling CHRP-based research to impact state policy for HIV/AIDS care and services.